BARET
Brain Imaging in Alcohol Responsive and Alcohol Resistant Essential Tremor...
Description
This study investigates pathophysiological differences between alcohol‑responsive and alcohol‑resistant essential tremor (ET) using a multimodal neuroimaging design. Participants undergo functional MRI in both a sober (OFF‑alcohol) and low‑dose alcoh...
General Design
- Type
- Cohort study
- Cohort type
- Clinical cohort
- Data collection type
- Prospective
- Design
- Longitudinal
- Design description
- A within‑subject ON/OFF alcohol design in which Essential Tremor patients undergo task‑based and resting‑state fMRI with simultaneous EMG and accelerometry. Alcohol‑responsive and alcohol‑resistant participants are compared in a multimodal neuroimaging framework to assess tremor‑related cerebellar activity and motor network connectivity. Alcohol responsivity is determined prior to scanning using a validated at‑home alcohol responsivity test. All participants undergo an in‑person neurological examination, and demographic as well as clinical data are collected as part of the study.
- Start/End data collection
- 2023 (ongoing)
Population
- Countries
- Netherlands (the)
- Number of participants
- 60
- Population age groups
- Adult (18+ years)
- Main medical condition
- No main medical condition
- VI Diseases of the nervous system
- G20-G26 Extrapyramidal and movement disorders
- G25.0 Other extrapyramidal and movement disorders - Essential tremor
- Other inclusion criteria
- Diagnosis of essential tremor
- Other exclusion criteria
- MRI-incompatibility, alcohol-related exclusion criteria
Organisations
Additional organisations
Contributors
Available Data & Samples
Data categories
- Imaging data
- Medical records
- Other
Subpopulations
List of subpopulations for this resource...
| Name | Description | Number of participants | |
|---|---|---|---|
No results for current selection |
Collection events
List of collection events defined for this resource...
| Name | Description | Participants | Start end year | |
|---|---|---|---|---|
No results for current selection |
Access conditions
Access to the data from this study is available to other researchers upon reasonable request. Access will be granted under the following conditions: 1. Scientific use only The data may be used solely for non‑commercial, scientific research. 2. Data ...
- Data access conditions
- health or medical or biomedical research
- Data use conditions
- not for profit, non commercial use only
- ethics approval required
- Data access fee
- false
- Release type
- Closed dataset
- Release description
- This study generates a finite, fixed dataset based on a single research protocol. Data collection will end once the last planned participants are included, after which no new data will be added.
Funding & Acknowledgements
- Funding
- Funded by a ZonMw Off Road grant (dr. M.M.M. van der Stouwe) and a Junior Scientific Masterclass MD/PhD grant (Sarah Jonker).