BARET

Brain Imaging in Alcohol Responsive and Alcohol Resistant Essential Tremor

Description

This study investigates pathophysiological differences between alcohol‑responsive and alcohol‑resistant essential tremor (ET) using a multimodal neuroimaging design. Participants undergo functional MRI in both a sober (OFF‑alcohol) and low‑dose alcohol (ON‑alcohol) condition, combined with MR‑compatible electromyography and accelerometry to quantify tremor severity during scanning. The study aims to determine whether alcohol responsiveness reflects a distinct neurobiological ET subtype, with a focus on cerebellar activity and cerebello‑thalamo‑cortical network connectivity. The resulting dataset provides high‑resolution neuroimaging and physiological recordings that support research into ET phenotype stratification, biomarker development, and mechanisms of tremor modulation.

General Design

Type
Cohort study
Cohort type
Clinical cohort
Data collection type
Prospective
Design
Longitudinal
Design description
A within‑subject ON/OFF alcohol design in which Essential Tremor patients undergo task‑based and resting‑state fMRI with simultaneous EMG and accelerometry. Alcohol‑responsive and alcohol‑resistant participants are compared in a multimodal neuroimaging framework to assess tremor‑related cerebellar activity and motor network connectivity. Alcohol responsivity is determined prior to scanning using a validated at‑home alcohol responsivity test. All participants undergo an in‑person neurological examination, and demographic as well as clinical data are collected as part of the study.
Start/End data collection
2023 (ongoing)
PID
https://doi.org/10.34760/69d60675243b5
External identifiers
METc number: 2023/100, NL83904.042.23

Population

Countries
Netherlands (the)
Number of participants
60
Population age groups
Adult (18+ years)
Main medical condition
  • No main medical condition
  • VI Diseases of the nervous system
Other inclusion criteria
Diagnosis of essential tremor
Other exclusion criteria
MRI-incompatibility, alcohol-related exclusion criteria

Organisations

Additional organisations

Contributors

Available Data & Samples

Data categories

  • Imaging data
  • Medical records
  • Other

Subpopulations

List of subpopulations for this resource
No results for current selection

Collection events

List of collection events defined for this resource
No results for current selection

Access conditions

Access to the data from this study is available to other researchers upon reasonable request. Access will be granted under the following conditions: 1. Scientific use only The data may be used solely for non‑commercial, scientific research. 2. Data Use Agreement (DUA) required The requester must sign a Data Use Agreement that includes: - no attempts to re‑identify participants; - no sharing or onward transfer of the data to third parties without prior written permission; - correct citation of the dataset and the original study; - responsibility for implementing appropriate data security measures, proportional to the sensitivity of the data. 3. Type of data shared Only anonymised data will be provided. 4. Scientific review Requests are evaluated by the Principal Leader (PL), who assesses the suitability, proportionality and feasibility of the proposed use. The projectleader reviews whether the intended use is consistent with the aims of the original study. 5. Ethical and legal requirements The requester must demonstrate that: - the proposed project has valid ethical approval (if applicable); - the intended use of the data is compatible with the conditions of the original informed consent. 6. Reporting and feedback obligations The requester agrees to: - report progress in case the project is delayed or cannot be completed; provide copies of publications and other relevant outputs as soon as they are available; - communicate the main research findings back to the original research team.
Data access conditions
health or medical or biomedical research
Data use conditions
  • not for profit, non commercial use only
  • ethics approval required
Data access fee
false
Release type
Closed dataset
Release description
This study generates a finite, fixed dataset based on a single research protocol. Data collection will end once the last planned participants are included, after which no new data will be added.

Funding & Acknowledgements

Funding
Funded by a ZonMw Off Road grant (dr. M.M.M. van der Stouwe) and a Junior Scientific Masterclass MD/PhD grant (Sarah Jonker).

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