Immunolines is a collaborative effort of clinical and research departments. We provide an overview of the available data‑biobanks in the UMCG from auto-immune and auto-inflammatory diseases together called IMID (Immune Mediated Inflammatory Diseases). Immunolines aims to facilitate translational research in and across IMID’s within and outside the UMCG. Our cohorts have as a central goal to increase the understanding of immune-mediated diseases including their variety in severity, involved organs and outcome upon treatment. This in order to facilitate translation and personalized care and increase awareness and collaboration on laboratory facilities for sampling and analysis of biological material.
Network detailsIMMUNOLINES - GLAS
Groningen Leeuwarden Axiale Spondyloartritis cohort
Description
The Groningen Leeuwarden Axial Spondyloarthritis (GLAS) cohort is an ongoing prospective longitudinal observational cohort study. This cohort is embedded in daily clinical practice and >900 patients are included in the northern part of the Netherlands.
Since November 2004, consecutive AS outpatients who started TNF-α blocking therapy because of active disease at the UMCG and the MCL were included in this cohort. In 2009, this inclusion was extended to all consecutive axial SpA outpatients, irrespective of treatment regimen. Patients treated with TNF-α blocking therapy are evaluated at baseline, after 3 and 6 months, and then every 6 to 12 months. Patients without anti-TNF-α treatment are evaluated every year. The standardized protocol consists of patient characteristics, medication use, questionnaires, physical examination, and biobanking (serum, plasma, DNA samples). Every 2-4 years, radiology of the pelvis and cervical, thoracic, and lumbar spine as well as BMD measurements of the lumbar spine and hip are performed.
Overall, our objective is to carefully monitor axial SpA and to gain more knowledge about the long-term course of the disease when patients are treated according to national (NVR) and international (ASAS, EULAR) guidelines.
General Design
- Type
- Biobank, Cohort study
- Cohort type
- Clinical cohort
- Data collection type
- Prospective
- Design
- Longitudinal
- Design description
- prospective longitudinal observational cohort study
- Start/End data collection
- 2004 (ongoing)
- PID
- https://doi.org/10.34760/6526684b19b66
Population
- Countries
- Netherlands (the)
- Regions
- Friesland, Groningen
- Number of participants
- 900
- Number of participants with samples
- 900
- Population age groups
- Adult (18+ years)
- Main medical condition
- XIII Diseases of the musculoskeletal system and connective tissue
- M40-M54 Dorsopathies
- M45-M49 Spondylopathies
- M45 Ankylosing spondylitis
- Other inclusion criteria
- 18 years or older, fulfilling the 1984 modified New York fort AS or the 2009 ASAS criteria for axSpA
Organisations
Lead organisations
- University Medical Center Groningen (UMCG)Netherlands (the)https://www.umcg.nl
Additional organisations
- Medisch Centrum Leeuwarden (MCL)Netherlands (the)https://www.mcl.nl/
Contributors
- dr. JPL (Anneke) SpoorenbergUniversity Medical Center Groningena.spoorenberg@umcg.nl
Principal Investigator, Primary contact
Available Data & Samples
Data categories
- Biological samples
- Survey data
- Imaging data
- Medical records
Sample categories
- Blood
- Plasma
- Serum
- Fluids and Secretions
- Urine
- Urine, random
- Genetic material
- DNA
Areas of information
- Administrative information
- Identifiers
- Date and time-related information
- Questionnaire and interview-related information
- Physical and cognitive measure and biosample-related information
- Data and sample collection center-related information
- Socio-demographic and economic characteristics
- Age/birthdate
- Sex/gender
- Lifestyle and behaviours
- Tobacco
- Physical activity
- Perception of health, quality of life, development and functional limitations
- Quality of life
- Functional limitations
- Medication and supplements
- Medication and supplement intake
- Death
- Vital status
- Physical measures and assessments
- Physical characteristics
- Muscles, skeleton and mobility
- Laboratory measures
- Other laboratory measures
Subpopulations
List of subpopulations for this resource
| Name | Description | Number of participants | |
|---|---|---|---|
No results for current selection |
Collection events
List of collection events defined for this resource
| Name | Description | Participants | Start end year | |
|---|---|---|---|---|
No results for current selection |
Networks
Part of networks
Access conditions
- Data access conditions
- disease specific research