CeDNN
Celiac Disease Northern Netherlands
Description
Celiac Disease Northern Netherlands, CeDNN, is collecting (bio)materials from celiac disease patients, relatives, partners and IBS patients. The aim is to get a better understanding of how CeD risk genes, the microbiome and environmental factors contribute to disease aetiology. To achieve this, a holistic approach will be applied in which we will study the behaviour of immune cells and the microbiome in CeD patients and compare that to non-patients using “omics” technology (i.e. the full repertoire of all transcripts, cytokine profiles, proteins, metabolites etc.) in the background of the genetic profile of each individual. To generate this information we will profile different immune cells from patients and controls. These datasets will be analysed and integrated using bioinformatics approaches to develop insights into the mechanisms underlying celiac disease. The hope is that the newly gained knowledge will contribute to disease prevention in patients with increased risk for developing celiac disease and to the discovery of novel treatment targets in patients that have developed disease already.
General Design
- Type
- Biobank, Cohort study
- Cohort type
- Case-control
- Data collection type
- Retrospective
- Design
- Cross-sectional
- Design description
- The aim of the CeDNN cohort is to include: - 500 CeD patients (adults and pediatrics) - 1,000 relatives (genetic control) - 500 partners (enviromental control) - 500 IBS patients (disease control)
- Design schematic
- Design schematic
- Start/End data collection
- 2015 (ongoing)
- PID
- https://doi.org/10.34760/6a16c5c5dd5bd
Population
- Countries
- Netherlands (the)
- Regions
- Gelderland, Drenthe, Friesland, Groningen
- Number of participants
- 706
- Number of participants with samples
- 706
- Population age groups
- All ages
- Other inclusion criteria
- - Patients suffering from CeD diagnosed by the treating physician according to established clinical, serological and pathological definitions. - Patients suffering from IBS as diagnosed by the treating physician according to established clinical defined in the Rome II criteria. -Spouses and 1st line family members of CeD patients - evidence of a personally signed and dated informed consent form, indicating that the subject (or a legal representative) has been informed of all the pertinent aspects of the study
- Other exclusion criteria
- -no informed consent obtained for this study -diagnosis other than CeD or IBS -severe psychiatric or physical illness -not being able to understand Dutch language
Organisations
Lead organisations
- University Medical Center Groningen (UMCG)Netherlands (the)https://www.umcg.nl
Contributors
Subpopulations
List of subpopulations for this resource
| Name | Description | Number of participants | |
|---|---|---|---|
No results for current selection |
Collection events
List of collection events defined for this resource
| Name | Description | Participants | Start end year | |
|---|---|---|---|---|
No results for current selection |
Publications
A large variety of clinical features and concomitant disorders in celiac disease - A cohort study in the Netherlands
High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation
Non-classical clinical presentation at diagnosis by male celiac disease patients of older age
Access conditions
Celiac Disease related research
- Data access conditions
- disease specific research
- Data use conditions
- research specific restrictions
- collaboration required
- ethics approval required
- time limit on use
- return to database or resource
- Release type
- Closed dataset