The Pulmolines cohort is the overarching cohort structure of the Groningen Research Institute for Asthma and COPD (GRIAC). The mission of GRIAC is the multidisciplinary translational study of obstructive airway and pulmonary diseases and healthy ageing. Pulmolines aims to contribute to research in the development, progression, remission, and treatment of lung diseases and helps to unravel the underlying mechanisms of airway obstruction, emphysema, allergies, and airway hyperresponsiveness.
WebsiteNetwork detailsPULMOLINES - SHERLOCk
An integrative genomic approach to Solve tHe puzzle of sevERe earLy-Onset COPD
Description
As part of the PULMOLINES banner the SHERLOCK cohort researches why some people are more likely to develop COPD. COPD is a chronic lung disease that includes symptoms like shortness of breath and coughing. Smoking is one of the most important causes of COPD yet not all smokers develop it. There is a proven genetic component to developing COPD but this does not explain why some patients develop mild, moderate or severe COPD, nor at what moment in their lives they develop this. The SHERLOCK cohort collects lung tissue of mild and moderate COPD patients to help identify the onset of COPD and to help discover better COPD medicine.
General Design
- Type
- Cohort study
- Cohort type
- Clinical cohort, Case only
- Data collection type
- Prospective
- Design
- Longitudinal
- Start/End data collection
- 2016 (ongoing)
- PID
- https://doi.org/10.34760/65265ac4c4d26
Population
- Countries
- Netherlands (the)
- Number of participants
- 580
- Number of participants with samples
- 580
- Population age groups
- Middle-aged (45-64 years), Aged (65+ years)
- Main medical condition
- X Diseases of the respiratory system
- J40-J47 Chronic lower respiratory diseases
- J44 Other chronic obstructive pulmonary disease
- J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
- J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
- J44.8 Other specified chronic obstructive pulmonary disease
- J44.9 Chronic obstructive pulmonary disease, unspecified
- Other inclusion criteria
- Respiratory healthy controls, mild-moderate COPD, Severe COPD with extensive emphysema, all ex-smokers
Organisations
Lead organisations
- University Medical Center Groningen (UMCG)Netherlands (the)https://www.umcg.nl
Contributors
- prof. dr. H.I. (Irene) Heijinkh.i.heijink@umcg.nl
- dr. S.D. (Daan) Pouwelss.d.pouwels@umcg.nl
- prof. dr. Dirk-Jan Slebosd.j.slebos@umcg.nl
- prof. dr. W. (Wim) Timensw.timens@umcg.nl
- prof. dr. M. (Maarten) van den BergeUniversity Medical Center Groningenm.van.den.berge@umcg.nl
Primary contact
Available Data & Samples
Data categories
- Medical records
- Physiological/Biochemical measurements
- Omics
- Genomics
- Transcriptomics
Subpopulations
List of subpopulations for this resource
| Name | Description | Number of participants | |
|---|---|---|---|
No results for current selection |
Collection events
List of collection events defined for this resource
| Name | Description | Participants | Start end year | |
|---|---|---|---|---|
No results for current selection |
Networks
Part of networks
Access conditions
- Data access conditions
- health or medical or biomedical research
- disease specific research
- Data use conditions
- collaboration required
- Data access fee
- false
- Release type
- Closed dataset