PULMOLINES - eQTL-Lung
eQTL Lung Consortium...
Description
The lung eQTL dataset has emerged from a research collaboration among investigators at Merck & Co. Inc. and three academic sites, namely Laval University, University of British Columbia, and University of Groningen. Human lung specimens were obtained...
General Design
- Cohort type
Clinical cohort, Case only, Biobank
- Design
Cross-sectional
- Design description
Human lung from patients who underwent lung surgery. Genome-wide gene expression and genotyping were performed to calculate lung expression quantitative trait loci (eQTL).
- Design schematic
- Design schematic
- Collection type
Retrospective
- Start/End year
1991 - 2008
- PID
https://doi.org/10.34760/65266407cb945
Population
- Countries
Netherlands (the), Canada
- Regions
Overijssel, Drenthe, Friesland, Groningen
- Number of participants
1400
- Number of participants with samples
1400
- Population age groups
Adult (18+ years)
- Main medical condition
- X Diseases of the respiratory system
- J40-J47 Chronic lower respiratory diseases
- J40 Bronchitis, not specified as acute or chronic
- J41 Simple and mucopurulent chronic bronchitis
- J41.0 Simple chronic bronchitis
- J41.1 Mucopurulent chronic bronchitis
- J41.8 Mixed simple and mucopurulent chronic bronchitis
- J42 Unspecified chronic bronchitis
- J43 Emphysema
- J43.0 Emphysema - MacLeod syndrome
- J43.1 Panlobular emphysema
- J43.2 Centrilobular emphysema
- J43.8 Other emphysema
- J43.9 Emphysema, unspecified
- J44 Other chronic obstructive pulmonary disease
- J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
- J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
- J44.8 Other specified chronic obstructive pulmonary disease
- J44.9 Chronic obstructive pulmonary disease, unspecified
- J45 Asthma
- J45.0 Predominantly allergic asthma
- J45.1 Nonallergic asthma
- J45.8 Mixed asthma
- J45.9 Asthma, unspecified
- J46 Status asthmaticus
- J47 Bronchiectasis
- J80-J84 Other respiratory diseases principally affecting the interstitium
- J80 Adult respiratory distress syndrome
- J81 Pulmonary oedema
- J82 Pulmonary eosinophilia, not elsewhere classified
- J84 Other interstitial pulmonary diseases
- J84.0 Other interstitial pulmonary diseases - Alveolar and parietoalveolar conditions
- J84.1 Other interstitial pulmonary diseases with fibrosis
- J84.8 Other specified interstitial pulmonary diseases
- J84.9 Interstitial pulmonary disease, unspecified
- J95-J99 Other diseases of the respiratory system
- J95 Postprocedural respiratory disorders, not elsewhere classified
- J95.0 Postprocedural respiratory disorders, not elsewhere classified - Tracheostomy malfunction
- J95.1 Postprocedural respiratory disorders, not elsewhere classified - Acute pulmonary insufficiency following thoracic surgery
- J95.2 Postprocedural respiratory disorders, not elsewhere classified - Acute pulmonary insufficiency following nonthoracic surgery
- J95.3 Postprocedural respiratory disorders, not elsewhere classified - Chronic pulmonary insufficiency following surgery
- J95.4 Postprocedural respiratory disorders, not elsewhere classified - Mendelson syndrome
- J95.5 Postprocedural subglottic stenosis
- J95.8 Other postprocedural respiratory disorders
- J95.9 Postprocedural respiratory disorder, unspecified
- J96 Respiratory failure, not elsewhere classified
- J96.0 Acute respiratory failure
- J96.1 Chronic respiratory failure
- J96.9 Respiratory failure, unspecified
- J98 Other respiratory disorders
- J98.0 Other respiratory disorders - Diseases of bronchus, not elsewhere classified
- J98.1 Other respiratory disorders - Pulmonary collapse
- J98.2 Other respiratory disorders - Interstitial emphysema
- J98.3 Other respiratory disorders - Compensatory emphysema
- J98.4 Other disorders of lung
- J98.5 Other respiratory disorders - Diseases of mediastinum, not elsewhere classified
- J98.6 Disorders of diaphragm
- J98.8 Other specified respiratory disorders
- J98.9 Respiratory disorder, unspecified
- J99 Respiratory disorders in diseases classified elsewhere
- J99.0 Respiratory disorders in diseases classified elsewhere - Rheumatoid lung disease
- J99.1 Respiratory disorders in other diffuse connective tissue disorders
- J99.8 Respiratory disorders in other diseases classified elsewhere
Contributors
- dr. M. (Maarten) van den Bergem.van.den.berge@umcg.nl
- prof. dr. W. (Wim) Timensw.timens@umcg.nl
- dr. C-A. (Corry-Anke) Brandsmac.a.brandsma@umcg.nl
Additional organisations
- University of British Columbia
Available Data & Samples
Data categories
- Biological samples
- Medical records
- Physiological/Biochemical measurements
- Omics
- Genomics
- Transcriptomics
Sample categories
- Tissue (Frozen)
- Respiratory System - Tissue (Frozen)
- Lung - Tissue (Frozen)
- Tissue (FFPE)
- Respiratory System - Tissue (FFPE)
- Lung - Tissue (FFPE)
Areas of information
- Socio-demographic and economic characteristics
- Age/birthdate
- Sex/gender
- Lifestyle and behaviours
- Tobacco
- Medication and supplements
- Medication and supplement intake
- Non-pharmacological interventions
- Surgical interventions
- Radiological interventions
- Laboratory diagnosis interventions
- Physical measures and assessments
- Physical characteristics
- Anthropometry
- Circulation and respiration
- Laboratory measures
- Histology
- Genomics
- Other laboratory measures
- Administrative information
- Identifiers
- Date and time-related information
- Physical and cognitive measure and biosample-related information
- Data and sample collection center-related information
- Other administrative information
Subpopulations
List of subcohorts or subpopulations for this resource...
| Name | Description | Number of participants |
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Collection events
List of collection events defined for this resource...
| Name | Description | Participants | Start end year |
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Partners
Networks
List of networks in which this cohort is involved...
Access conditions
It is possible to establish a collaboration with investigators from the lung eQTL consortium for any queries about the dataset that cannot be obtained from the QTLportal. Please fill the request form to be obtained from the PI: Wim Timens: w.timens@u...
- Data access conditions
- health or medical or biomedical research
- disease specific research
- Data use conditions
- publication required
- collaboration required
- user specific restriction
- project specific restriction
- Release type
- Closed dataset
- Linkage options
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001745.v1.p1
Funding & Acknowledgements
- Funding
Merck Research Laboratories paid for almost all molecular data acquisition and provided the compute cluster that performed much of the analyses. However, Merck as an institution had no role in study designs, data collection and analysis, decision to publish, or preparation of manuscripts.
- Acknowledgements
If you use the Lung eQTL Portal in your publication please cite our manuscript: Hao K*, Bossé Y*, Nickle D*, Paré PD, Postma DS, Laviolette M, Sandford A, Hackett TL, Daley D, Hogg JC, Elliott M, Couture C, Lamontagne M, Brandsma CA, van den Berge M, Koppelman G, Reicin AS, Nicholson DW, Malkov V, Derry JM, Suver C, Tsou JA, Kulkarni A, Zhang C, Vessey R, Opiteck GJ, Curtis SP, Timens W, Sin DD. Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genetics 2012; 8(11):e1003029. PMID 23209423