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NELSON

Nederlands-Leuvens Longkanker ScreeningsONderzoek / The Dutch-Belgian Randomized Lung Cancer Screening Trial...

Description

The Dutch-Belgian Randomized Lung Cancer Screening Trial (NELSON study) was designed to investigate whether screening for lung cancer by low-dose multidetector computed tomography (CT) in high-risk subjects and led to a decrease in ten year lung canc...

General Design

Type
Clinical trial
Data collection type
Prospective
Design
Longitudinal
Design description
Participants were randomized 1:1 in a screening and control group. Participants who were selected for screening were invited to undergo low-dose CT scanning of the chest at baseline, at 1, 3, and 5.5 years after the baseline.
Design schematic
Design schematic
Start/End data collection
2000 until 2015
Design paper
Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON)
PID
https://doi.org/10.34760/65266b301390b

Population

Countries
Netherlands (the)
Number of participants
15792
Population age groups
Middle-aged (45-64 years), Aged (65-79 years)
Other inclusion criteria
More specifically, the population comprised of people born between 1928 and 1956 originating from the Netherlands and Belgium, who: • Smoked > 15 cigarettes/day during > 25 years, • Or smoked > 10 cigarettes/day during > 30 years, • and were current smokers or former smokers who quit smoking ≤ 10 years ago. Excluded were those with a moderate or bad self-reported health who were unable to climb two flights of stairs, those with a body weight ≥ 140 kg, with current or past renal cancer, melanoma or breast cancer, or with lung cancer diagnosed less than 5 years ago, or 5 years or more ago but still under treatment. Also those who had a chest CT examination less than one year before they filled in the first NELSON questionnaire were excluded.

Organisations

Lead organisations
Additional organisations

Contributors

Available Data & Samples

Data categories

  • Biological samples
  • Survey data
  • Imaging data
  • Medical records
  • National registries
  • Omics

Sample categories

  • Genetic material

Areas of information

  • Socio-demographic and economic characteristics
  • Lifestyle and behaviours
  • Perception of health, quality of life, development and functional limitations
  • Death
  • Physical measures and assessments
  • Laboratory measures
  • Physical environment
  • Administrative information

Subpopulations

List of subpopulations for this resource...

Collection events

List of collection events defined for this resource...

Publications

Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON)

Access conditions

The University Medical Centre Groningen maintains individual data, which the NELSON steering committee can make available upon request....

Data access conditions
  • health or medical or biomedical research
  • disease specific research
Data use conditions
research specific restrictions
Data access fee
true
Release type
Closed dataset

Funding & Acknowledgements

Funding
Supported by the Netherlands Organization of Health Research and Development, the Dutch Cancer Society (KWF Kankerbestrijding), the Health Insurance Innovation Foundation (Innovatiefonds Zorgverzekeraars), G.Ph. Verhagen Stichting, the Rotterdam Oncologic Thoracic Study Group, the Erasmus Trust Fund, Stichting tegen Kanker, Vlaamse Liga tegen Kanker, and Lokaal Gezondheids Overleg (LOGO) Leuven. Siemens Germany provided four workstations and software for volume measurements.
This database was created using MOLGENIS.org ( github ).
Please cite Swertz & Gini (2022) , Van der Velde et al (2018) or Swertz et al (2010) on use.