LLNEXT
Lifelines NEXT...
Description
Lifelines NEXT (LLNEXT) is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease as epidemiological research has shown there is a strong relationship between pre-conceptional, prenatal, birth and e...
General Design
- Cohort type
Population cohort, Birth cohort, Biobank
- Design
Longitudinal
- Design description
Upon giving informed concent, the LLNEXT participants are asked to fill in questionnaires and donate biomaterials at several time points during pregnacy, at birth and after delivery of themselves and their child.
- Design schematic
- Design schematic
- Collection type
Prospective
- Start/End year
2016 - 2025
- Design paper
- Lifelines NEXT: a prospective birth cohort adding the next generation to the three‑generation Lifelines cohort study
- PID
https://doi.org/10.34760/652669f94ba18
Population
- Countries
Netherlands (the)
- Regions
Drenthe, Friesland, Groningen
- Number of participants
1450
- Number of participants with samples
1450
- Population age groups
Infant (0-23 months), Young adult (18-24 years), Adult (25-44 years), Middle-aged (45-64 years)
- Main medical condition
- No main medical condition
Contributors
- prof. dr. S.A. (Menno) Reijnevelds.a.reijneveld@umcg.nl
- drs. J.A.M. (Jackie) Dekensj.a.m.dekens@umcg.nl
- dr. S.J. (Sanne) Gordijns.j.gordijn@umcg.nl
- prof. dr. G.H. (Gerard) Koppelmang.h.koppelman@umcg.nl
- prof. dr. A (Alexandra) Zhernakovaa.zhernakova@umcg.nl
- drs. SA (Soesma) Jankipersadsings.a.jankipersadsing@umcg.nl
Additional organisations
- Lifelines Biobank
Available Data & Samples
Data categories
- Biological samples
- Survey data
- Omics
- Genomics
- Proteomics
- Metabolomics
- Imaging data
- Physiological/Biochemical measurements
- Other
- Medical records
Sample categories
- Fluids and Secretions
- Blood
- Blood (whole)
- Blood Buffy Coat
- Serum
- Plasma
- Fetal blood (Cord blood)
- Feces
- Urine
- Urine, random
- Milk, Human
- Mouth swabs
- Nasal swabs
- Genetic material
- DNA
- RNA
- Cells
- Epithelial Cells
- Other epithelium
- Tissue (Frozen)
- Genitalia, Female - Tissue (Frozen)
- Vagina - Tissue (Frozen)
- Placenta - Tissue (Frozen)
Areas of information
- Lifestyle and behaviours
- Nutrition
- Breastfeeding
- Sleep
- Tobacco
- Alcohol
- Drugs
- Physical activity
- Sexual behaviours and orientation
- Laboratory measures
- Microbiology
- Virology
- Immunology
- Genomics
- Biochemistry
- Preschool, school and work life
- Work life
- Administrative information
- Date and time-related information
- Questionnaire and interview-related information
- Identifiers
- Perception of health, quality of life, development and functional limitations
- Perception of health
- Life course development
- Medication and supplements
- Medication and supplement intake
- Physical measures and assessments
- Skin and subcutaneous tissue
- Anthropometry
- Cognition, personality and psychological measures and assessments
- Psychological distress and emotions
- Social environment and relationships
- Parenting and familial environment
- Social support
- Socio-demographic and economic characteristics
- Marital/partner status
- Family and household structure
- Education
- Residence
- Income, possessions, and benefits
- Age/birthdate
- Sex/gender
- Twin
- Birthplace
- Ethnicity, race and religion
- Life events, life plans, beliefs and values
- Life events
- Birth, pregnancy and reproductive health history
- Puberty, menstruation, menopause and andropause
- Contraception
- Pregnancy, delivery and birth
- Fertility and sexual health
- Health and community care services utilization
- Hospitalizations
- Physical environment
- Housing characteristics
Subpopulations
List of subcohorts or subpopulations for this resource...
| Name | Description | Number of participants |
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Collection events
List of collection events defined for this resource...
| Name | Description | Participants | Start end year |
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Partners
Access conditions
- Data access conditions
health or medical or biomedical research
- Data use conditions
- research specific restrictions
- publication required
- collaboration required
- ethics approval required
- time limit on use
- user specific restriction
- project specific restriction
- return to database or resource
- Data access fee
true
- Release type
- Continuous
- Release description
Lifelines NEXT is currently collecting data. Until then, data is being added to the database and biobank until collection is completed.
- Linkage options
Lifelines, GBA, CBS, GGD
Funding & Acknowledgements
- Funding
The following funding agencies were used to build the LLNEXT cohort and generate samples. LLNEXT The data collection of the core study was funded by a grant from the UMCG Hereditary Metabolic Diseases Fund and by grants awarded to Alexandra Zhernakova: VIDI Grant [016.178.056] from the Netherlands Organization for Scientific Research [NWO], European Research Council [ERC] starting Grant [ERC-715772], and Gravitation program EXPOSOME-NL (NWO grant number 024.004.017). Dependent on the research question and the data used, the recipient shall acknowledge the corresponding funds that made the recipients’ research possible. Living Lab Newborn Funding for the Newborn project, including inclusion of fathers, was provided by the European Union, the Northern Netherlands Alliance (SNN), the provinces of Friesland and Groningen and the municipality of Groningen. Furthermore, Philips provided continuous measurement devices for this add-on initiative. Nestlé NEXT LLNEXT is powered by Nestlé. The collaboration with Nestlé (Nestlé NEXT) is awarded with the Public-Private Partnerships (PPP) Allowance made available by Health~Holland (Top Sector Life Sciences & Health).
- Acknowledgements
The data and biological samples used in this manuscript are provided by LLNEXT. The authors are grateful for the participation of all the parents and children in LLNEXT. We also thank the LLNEXT team and maternity care providers for recruiting participants, collecting material during and after childbirth and building and maintaining the cohort.