LLNEXT
Lifelines NEXT...
Description
Lifelines NEXT (LLNEXT) is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease as epidemiological research has shown there is a strong relationship between pre-conceptional, prenatal, birth and e...
General Design
- Type
- Biobank, Cohort study
- Cohort type
- Population cohort, Birth cohort
- Data collection type
- Prospective
- Design
- Longitudinal
- Design description
- Upon giving informed concent, the LLNEXT participants are asked to fill in questionnaires and donate biomaterials at several time points during pregnacy, at birth and after delivery of themselves and their child.
- Design schematic
- Design schematic
- Start/End data collection
- 2016 until 2025
- Design paper
- Lifelines NEXT: a prospective birth cohort adding the next generation to the three‑generation Lifelines cohort study
- PID
- https://doi.org/10.34760/652669f94ba18
- External identifiers
- METc number: METc2015/600
Population
- Countries
- Netherlands (the)
- Regions
- Drenthe, Friesland, Groningen
- Number of participants
- 1450
- Number of participants with samples
- 1450
- Population age groups
- Infant (0-23 months), Young adult (18-24 years), Adult (25-44 years), Middle-aged (45-64 years)
- Main medical condition
- No main medical condition
- Other inclusion criteria
- Pregnant Living in the northern provinces of the Netherlands (Groningen, Friesland, Drenthe) Willing and able to fill in (digital) questionnaires Willing and able to collect biomaterials from themselves and the enrolled child
Organisations
Lead organisations
- University Medical Centre Groningen (UMCG)Netherlands (the)https://www.umcg.nl/
Additional organisations
- Lifelines Biobank (Lifelines)Netherlands (the)https://www.lifelines.nl/
Contributors
- prof. dr. A (Alexandra) ZhernakovaUniversity Medical Centre Groningena.zhernakova@umcg.nl
Principal Investigator
- drs. SA (Soesma) JankipersadsingUniversity Medical Centre Groningens.a.jankipersadsing@umcg.nl
Primary contact
Available Data & Samples
Data categories
- Biological samples
- Survey data
- Imaging data
- Medical records
- Physiological/Biochemical measurements
- Omics
- Genomics
- Proteomics
- Metabolomics
- Other
Sample categories
- Blood
- Blood (whole)
- Blood Buffy Coat
- Fetal blood (Cord blood)
- Plasma
- Serum
- Cells
- Epithelial Cells
- Other epithelium
- Fluids and Secretions
- Feces
- Milk, Human
- Mouth swabs
- Nasal swabs
- Urine
- Urine, random
- Genetic material
- DNA
- RNA
- Tissue (Frozen)
- Genitalia, Female - Tissue (Frozen)
- Placenta - Tissue (Frozen)
- Vagina - Tissue (Frozen)
Areas of information
- Socio-demographic and economic characteristics
- Age/birthdate
- Sex/gender
- Twin
- Marital/partner status
- Family and household structure
- Education
- Residence
- Birthplace
- Ethnicity, race and religion
- Income, possessions, and benefits
- Lifestyle and behaviours
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Birth, pregnancy and reproductive health history
- Puberty, menstruation, menopause and andropause
- Contraception
- Pregnancy, delivery and birth
- Fertility and sexual health
- Perception of health, quality of life, development and functional limitations
- Perception of health
- Life course development
- Medication and supplements
- Medication and supplement intake
- Health and community care services utilization
- Hospitalizations
- Physical measures and assessments
- Anthropometry
- Skin and subcutaneous tissue
- Laboratory measures
- Biochemistry
- Microbiology
- Virology
- Immunology
- Genomics
- Cognition, personality and psychological measures and assessments
- Psychological distress and emotions
- Life events, life plans, beliefs and values
- Life events
- Preschool, school and work life
- Work life
- Social environment and relationships
- Social support
- Parenting and familial environment
- Physical environment
- Housing characteristics
- Administrative information
- Identifiers
- Date and time-related information
- Questionnaire and interview-related information
Subpopulations
List of subpopulations for this resource...
| Name | Description | Number of participants |
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Collection events
List of collection events defined for this resource...
| Name | Description | Participants | Start end year |
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Publications
Access conditions
- Data access conditions
- health or medical or biomedical research
- Data use conditions
- research specific restrictions
- publication required
- collaboration required
- ethics approval required
- time limit on use
- user specific restriction
- project specific restriction
- return to database or resource
- Data access fee
- true
- Release type
- Continuous
- Release description
- Lifelines NEXT is currently collecting data. Until then, data is being added to the database and biobank until collection is completed.
- Linkage options
- Lifelines, GBA, CBS, GGD
Funding & Acknowledgements
- Funding
- The following funding agencies were used to build the LLNEXT cohort and generate samples. LLNEXT The data collection of the core study was funded by a grant from the UMCG Hereditary Metabolic Diseases Fund and by grants awarded to Alexandra Zhernakova: VIDI Grant [016.178.056] from the Netherlands Organization for Scientific Research [NWO], European Research Council [ERC] starting Grant [ERC-715772], and Gravitation program EXPOSOME-NL (NWO grant number 024.004.017). Dependent on the research question and the data used, the recipient shall acknowledge the corresponding funds that made the recipients’ research possible. Living Lab Newborn Funding for the Newborn project, including inclusion of fathers, was provided by the European Union, the Northern Netherlands Alliance (SNN), the provinces of Friesland and Groningen and the municipality of Groningen. Furthermore, Philips provided continuous measurement devices for this add-on initiative. Nestlé NEXT LLNEXT is powered by Nestlé. The collaboration with Nestlé (Nestlé NEXT) is awarded with the Public-Private Partnerships (PPP) Allowance made available by Health~Holland (Top Sector Life Sciences & Health).
- Acknowledgements
- The data and biological samples used in this manuscript are provided by LLNEXT. The authors are grateful for the participation of all the parents and children in LLNEXT. We also thank the LLNEXT team and maternity care providers for recruiting participants, collecting material during and after childbirth and building and maintaining the cohort.