DUPARC

Dutch Parkinson Cohort...

Description

The DUPARC study is a single center, prospective, observational study of newly diagnosed patients with Parkinson's disease with follow-up after one year and three years, with the intention of an extended follow-up with three-year intervals. The DUPAR...

General Design

Cohort type

Clinical cohort

Design

Longitudinal

Design description

DUPARC is a prospective cohort study in which 150 de novo PD subjects are included. Participants receive follow-up assessments after 1 year and 3 years, with the intention of an extended follow-up with 3 year intervals. Subjects are extensively characterized to primarily assess objectives within three major domains of PD: cognition, gastrointestinal function and vision.

Design schematic
Design schematic
Start/End year

2017 - ongoing

Design paper
Study protocol of the DUtch PARkinson Cohort (DUPARC): a prospective, observational study of de novo Parkinson's disease patients for the identification and validation of biomarkers for Parkinson's disease subtypes, progression and pathophysiology
PID

https://doi.org/10.34760/6526633dab6fe

Population

Countries

Netherlands (the)

Regions

Drenthe, Friesland, Groningen

Number of participants

150

Number of participants with samples

150

Population age groups

Adult (18+ years)

Main medical condition
  • VI Diseases of the nervous system

Contributors

Additional organisations

  • Parkinson Platform Noord Nederland

Available Data & Samples

Data categories

  • Biological samples
  • Imaging data
  • Other

Sample categories

  • Fluids and Secretions

Areas of information

  • Socio-demographic and economic characteristics
  • Lifestyle and behaviours
  • Perception of health, quality of life, development and functional limitations
  • Medication and supplements
  • Physical measures and assessments
  • Laboratory measures
  • Cognition, personality and psychological measures and assessments
  • Administrative information

Subpopulations

List of subcohorts or subpopulations for this resource...

Collection events

List of collection events defined for this resource...

Partners

Funding & Acknowledgements

Funding

The DUPARC study is funded by two grants from the W. Garfield Weston Foundations’ Weston Brain Institute. JMB has received personal grants to cover personnel costs. AC has received funding for personnel costs by the European Union Horizon 2020 grant No 661883, European Glaucoma Research Training Program (EGRET). No funding agency was involved in the design of the study; the collection, analysis and interpretation of data; or in writing the manuscript.

Acknowledgements

We thank all patients, caregivers, health care professionals, students and institutions who have contributed and collaborated in this project. In particular, we would like to thank Renée Speijers, Yvonne Nijman and Hanna Slomp for their help in the recruitment and logistics of the study. The Parkinson Platform Northern Netherlands (PPNN) Study Group collaborators. Verwey NA1, Van Harten B1, Portman AT2, Langedijk MJH2, Oomes PG2, Jansen BJAM2, Van Wieren T2, Van den Bogaard SJA3, Van Steenbergen W3, Duyff R3, Van Amerongen JP3, Fransen PSS4, Polman SKL4, Zwartbol RT4, Van Kesteren ME4, Braakhekke JP4, Trip J4, Koops L4, De Langen CJ4, De Jong G4, Hartono JES4, Ybema H4, Bartels AL5, Reesink FE5, Postma AG6, Vonk GJH7, Oen JMTH7, Brinkman MJ7, Mondria T7, Holscher RS7, Van der Meulen AAE8, Rutgers AWF8, Boekestein WA9, Teune LK9, Orsel PJL10, Hoogendijk JE10, Van Laar T11. 1Department of Neurology, Medisch Centrum Leeuwarden, Leeuwarden, the Netherlands; 2Department of Neurology, Treant Zorggroep locations, Stadskanaal, Emmen, Hoogeveen, the Netherlands; 3Department of Neurology, Tjongerschans Ziekenhuis Heerenveen, Heerenveen, the Netherlands; 4Department of Neurology, Isala, Zwolle, Meppel, the Netherlands; 5Department of Neurology, Ommlander Ziekenhuis Groningen, Scheemda, the Netherlands; 6Department of Neurology, Nij Smellinghe Ziekenhuis Drachten, Drachten, the Netherlands; 7Department of Neurology, Antonius Zorggroep, Sneek, the Netherlands; 8Department of Neurology, Martini Ziekenhuis, Groningen, the Netherlands; 9Department of Neurology, Wilhelmina Ziekenhuis Assen, Assen, the Netherlands; 10Department of Neurology, Sionsberg, Dokkum, the Netherlands; 11Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands.